AstraZeneca sells rights to high cholesterol treatment for up to US$350mln
Germany's Grünenthal will be able to sell Crestor in over 30 countries in Europe, except the UK and Spain
Company
LON:AZN
AstraZeneca is one of the world's leading pharmaceutical companies, with a broad range of medicines designed to fight disease. AstraZeneca has over 67,000 empolyees and operates in over 100 countries with growing presence in important emerging markets.
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Germany's Grünenthal will be able to sell Crestor in over 30 countries in Europe, except the UK and Spain
After a fall in the shares they are now on a more “palatable” 13% premium to the sector based on 2024 forecast earnings
The results announced earlier this week have sparked criticism across the scientific community
The pharma giant will look to confirm the 90% efficacy rate the vaccine candidate showed in a questioned portion of initial trials
In the trial that achieved 90% efficacy, there were only 2,300 participants all aged below 55
The pharma giant could reap the long-term benefits from higher reputation – ‘no vax’ movements aside – and the economic ties with governments worldwide
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The FTSE 100 firm dipped after posting lower efficacy than its competitors, but the upside lies in the bigger picture
The jab protected participants from the virus 14 days or more after receiving two doses of the vaccine
Patients will be able to go to hospital to receive treatment once per month rather than every two weeks
Data on the final stage of clinical trials is expected soon
Analysts said the results should come in “days to weeks” after discussing with the pharma giant’s chief financial officer Marc Dunoyer
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Nudging up the valuation by 140p to 7,260p each, the bank said the main oncology pillars of the group – Lynparza, Tagrisso and Imfinzi – showed robust growth in the third quarter
The drug candidate, developed with Amgen, was found to be effective and safe
It would first be distributed to care home residents, people over 80 and healthcare workers
The green light follows positive results from two Phase III clinical trials and a recommendation for approval by an EU committee
The US Food & Drug Administration green light followed a successful phase III study of the drug, also known as ticagrelor, in combination with aspirin
The drugs firm said it is on track to achieve full-year results in line with guidance despite quarterly revenue only being up 3%
Reports yesterday suggested the GPs had been told to prepare to administer a COVID-19 vaccine before Christmas.
The buyer is German pharma company Cheplapharm while the agreement will cover over 70 countries
Efficacy read-outs from the final phase of trials are expected "between now and the end of the year"
Health Secretary Matt Hancock said vaccinating health workers was not his “central expectation” though he did not rule it out
It is being investigated as an additional treatment of patients with early-stage non-small cell lung cancer
The recommendation was based on final-stage trial results for both Forxiga and Trixeo Aerosphere
The US government has provided funding of US$486mln to progress the studies
The pair are developing cancer drug DS-1062 as part of a US$6bn partnership
The organisation partnered with five clinical laboratories worldwide
A trial of the vaccine has already been halted in the US
The candidate showed promising results in early trials
Big pharma is forecast to return 46% of operating cash flow in the form of dividends and 10% in share buybacks between 2020 and 2024
There are more than six vaccines in late-stage trials currently
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US scientists are concerned about the potential neurological adverse effects of the jab
Lynparza is recommended for marketing authorisation for ovarian and prostate cancer, while Tagrisso showed positive results in late-stage trials for lung cancer
The Medicines Health Regulatory Authority has advised it was safe to restart the tests
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The pharma giant is looking to cut costs, while it also announced “high-level” results for its rhinosinusitis candidate
The pharma giant said it is standard routine to allow review of safety data to ensure the integrity of the trials
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Britain's top share index closed over 82 points higher at 6,012 midweek
Both agreements, for a UK formulation and a local one, are worth £900mln
The pharma giant also announced exceptional results for Farxiga in patients with chronic kidney disease
The deal includes an option for a further 100 million doses
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Partner AstraZeneca has also denied discussions with US authorities for a fast-track approval
AZD7442’s combination of mAbs was derived from convalescent patients with SARS-CoV-2 infection
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Britain's blue chip benchmark erased most of yesterday's gains to close down over 67 points at 6,037, down 1.11% on the day
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All three US benchmarks finished higher in New York, while Apple increase 1.2% to $503 a share
In the first half of 2020, Imfinzi was one of the company's best-selling medicines, generating US$954mln of revenues
The EU is also in talks with Johnson & Johnson and Sanofi and has agreed advanced purchase deal with AstraZeneca for at least 300mln shots of the drug it is developing with the University of Oxford
The issue is part of a three-tranche global bond offering totalling $3bn that is expected to close on 6 August.
Oncology continued to be the star, growing sales 28% to US$5.3bn or 42% of total group revenue
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The index of UK blue-chips dropped 142 points to finish at 5,990
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AstraZeneca, Shell and Lloyds are among the notable names in Thursday's diary.
Farxiga was reported to show “a statistically significant and clinically meaningful effect” to prevent renal function from worsening or risk of death
The pair will jointly develop and commercialise a candidate for non-small cell lung cancers and breast cancers
Other updates are expected from BT, GSK, Next, Ryanair and Aston Martin, plus a US Fed meeting and a busy Wall Street earnings week including Apple and Alphabet
Breztri Aerosphere, a triple-combination inhaled treatment, showed significant improvements over dual-combination therapies in the phase III KRONOS/ETHOS trials.
Claims that the Oxford-AstraZeneca vaccine offers “dual protection” is totally unsubstantiated
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Britain's blue-chip benchmark finished the day up around eight points, or 0.13%, at 6,268
The UK has already ordered 100 million doses of the vaccine, called AZD1222
The treatment targets the 5-7% of patients with pancreatic cancer who have a germline BRCA mutation
Thursday's main news on vaccines development to tackle the pandemic
Just ten blue chip stocks are forecast to pay 55% of the index's forecast total for 2020
Deliveries will begin at the end of 2020 to countries wishing to take part in the initiative
It can even take a decade to find a suitable formulation against a certain disease, so reaching the final phase of trials in a matter of months is "unbelievably quick", says top scientist
“Gilead needs a pipeline (which AZN has) and AZN could be looking for cash, not least to cover its dividend,”
A deal would create a business worth around US$240bn and bring together two of the companies leading the way in the fight against coronavirus.
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Britain's blue chip benchmark finished down over 11 points at 6,472 having been in positive territory earlier
The pharma giant is producing the candidate developed by Oxford University, which is to release results on the second phase of trials by next month
Analysts confirmed the forecast of US$8bn yearly sales but US$12bn upside “is going to be tough”
The pharma giant shared news on Enhertu, Imfinzi and Tagrisso, with the latter showing impressive results on reducing the risk of death in patients with a certain type of cancer
Tagrisso reduced the risk of disease recurrence or death by 83%
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Expenses for the vaccine, which will not be produced for a profit during the pandemic, are expected to be offset by funding by governments
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The pharma giant also announced Bevespi Aerosphere was approved in China for patients with chronic obstructive pulmonary disease
The firm also announced it completed the recovery of global rights to brazikumab while its candidate Enhertu received a fast-track designation
Farxiga has been shown to reduce the risk of death and hospitalisation for cardiovascular patients with a condition called reduced ejection fraction
The pharma giant would be responsible for the development and worldwide manufacturing and distribution of the candidate, if and when it is approved
It is also said it is committed to a progressive dividend policy
Arix is a backer of innovative smaller life sciences companies developing potentially breakthrough new medicines
Lynparza successfully achieved a second goal when deployed to treat men with an advanced form of the disease
“This is the fastest launch of any clinical trial in the history of AstraZeneca," according to José Baselga, the group's executive vice president in the oncology research and development segment
The broker, which retains a 'buy' recommendation, said the pharma giant is expected to be “a long-term outperformer”
The pharma company also announced Imfinzi has been approved for small cell lung cancer in combination with chemotherapies
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A look back at some of the more interesting stories from London's junior market this week
The base drug for the treatment is being tested in conjunction with chemotherapy in patients with the same disease
The initial US$350mln payment may be followed by optional instalments of up to US$40mln based on sales
AstraZeneca will retain rights to sell Movantik in Europe, Canada and Israel
Sales will be driven by cancer drugs Enhertu, Lynparza and selumetinib in various markets and anaemia treatment Roxadustat in China
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Britain's blue-chip index closed down nearly 43 points at 7,409. The FTSE 250, conversely, went higher, gaining over 116 points at 21,790
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The two FTSE 100 constituents are scheduled to release their final results
Other updates on the coming week's agenda include Ocado, TUI, Babcock and Dunelm
The new arrangement will see Allergan still fund the development costs incurred by AstraZeneca
Imfinzi and tremelimumab are now 'orphan drugs', meaning their development becomes a matter of public policy because they cure a rare disease
Credit Suisse said AZN's “top-line growth and underlying margin potential” made it the top firm in their assessments
An independent data monitoring committee recommended to stop phase III of the trial on Epanova, which is still marketed in the US for other treatments
It has received a fast-track review of a diabetes drug while gaining approval for a blood treatment in China
“Lynparza is now the only approved targeted medicine in biomarker-selected patients with advanced pancreatic cancer," said AstraZeneca's Dave Fredrickson.
AstraZeneca and Daiichi Sankyo are exploring the further potential of Enhertu in HER2-breast cancer with three ongoing Phase III trials
The FTSE 100-listed firm already sold commercial rights in the US in 2017, while now the drugs have lost exclusive rights in most countries in Europe and Africa