Scancell Holdings doses first patient with second Covid vaccine candidate
It also said no safety concerns emanated from the first group of trial volunteers
Company
LON:SCLP
Scancell is a clinical stage biotech company developing immunotherapies for a cancer-free future by enhancing long-lasting tumour specific immunity. With deep roots in cancer immunology and translational research, the company aims to translate its innovation and creativity to address the need for fast, potent and accessible therapies that are easy to administer in hard-to-treat cancers.
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It also said no safety concerns emanated from the first group of trial volunteers
The company provided the update alongside its interim results
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The company's SCIB1 discovery will be used in combination with checkpoint inhibitor drug Keytruda
The pharma group will use the capital raised via the issue of shares and convertible loan notes earlier in the financial year to pursue several clinical programmes
Oxford "is the perfect location for Scancell's expansion, with access to an excellent local talent pool as we grow the business", said CEO Lindy Durrant
Chief executive, Professor Lindy Durrant, said: "The approval of the Modi-1 clinical trial application is a significant achievement for the company.”
It will use technology pioneered by PharmaJet in the COVIDITY phase I clinical trial
Professor Lindy Durrant, who takes the position with immediate effect, previously served as co-CEO of the firm
The two-part study, which is set to get underway sometime in the second half, will look at both safety and immunogenicity – the ability to provoke an immune response
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“Our next-generation COVID-19 vaccine has the potential to work alongside currently approved vaccines by protecting the population against new variants of SARS-CoV-2," said chief executive, Dr Cliff Holloway
The decision to curtail clinical development work on Scancell target SCIB2 followed a re-assessment of the charity’s collaboration model in the wake of the coronavirus pandemic, the company said
For the six months ended October 31, the developer of immunotherapies said it had ended the period with £25.7mln in cash compared to £3.6mln in April last year, while post-period another £20.5mln had been raised
Companies in the diagnostics, treatment and vaccines space have posted positive news this week
As a second-generation vaccine, Scancell believes SN14 offers several potential advantages over currently approved and late-stage vaccines
"We are excited by the advice and guidance that Gillies and Robert will be able to provide in advancing these trials and look forward to working with them," said CEO Cliff Holloway
The directors said they are aware of a number of shareholders who have indicated that they would vote in favour if more time was available
The company, which has received tremendous support from its shareholders, expects to make further progress in the current year as it looks to broaden the reach of its platforms
An additional £3mln open offer will provide existing investors with the chance to acquire new stock in the business
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The agreement covers the good manufacturing pracatice (GMP) production of plasmid DNA needed to generate the inoculation against SARS-CoV-2
The funding for a team, led by chief scientific officer, Prof Lindy Durrant, is coming from Innovate UK
The cash will also be used to support the company's Modi-1 and SCIBI clinical trials
Scancell is preparing a regulatory submission for a phase I/II clinical study in the UK in the first half of 2021.
The paper describes how AvidiMab modifications improve an antibody’s potential therapeutic properties
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The company is anticipating a phase 1 clinical trial in the first quarter of 2021
The US Food & Drug Administration has granted investigational new drug status to the firm's lead drug, SCIB1
The update was provided alongside the firm’s interim results, which charted a busy period for the immunotherapies specialist, one in which it brought on board a new major shareholder, the Vulpes Life Science Fund
The US firm will conduct preclinical studies to evaluate whether antibodies developed by Scancell's AvidiMab platform can treat cancer
This is the company's second research agreement, following the first in September
"The utility of the Moditope technology is increasingly being recognised as a novel and important immuno-therapeutic approach in the treatment of cancer, as evidenced by the expansion of our patent portfolio and selection for presentation o
Dr Ursula Ney joins the immunotherapies specialist with immediate effect, replacing Dr Matthew Frohn who stands down from end October
The company is teaming up with an unnamed "major player" in the world of antibodies
A £3.9mln injection from the life sciences fund Vulpes will effectively bankroll the latest R&D
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Discussions with US regulators have taken longer than expected, so Scancell will now focus its efforts on completing the UK arm of the trial before re-submitting its US application at a later date
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The immunotherapy specialist gave an update on progress for a “busy and productive” half-year.
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The UK's premier share index closed around 73 points higher at 7,499, while FTSE 250 was also up - around 170 points to 19,632
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“At Vulpes we are always searching for overlooked companies that have the ability to make significant advances in medical science, with a view to supporting their development over the long term. We believe Scancell fulfil these criteria per
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Essentially, immuno-oncology involves developing drugs that use the body’s own immune system to fight cancers
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Scancell has a clinical development partnership with Cancer Research UK, the world's leading cancer charity dedicated to saving lives through research
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The UK index of leading shares closed down nearly 38 points at 7,310
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“The initial focus of the board will be to inform the clinical strategy for the planned Modi-1 clinical trial and to ensure the best possible outcome in several solid tumour indications”
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The mid-stage study is testing Scancell’s flagship skin cancer immunotherapy in combination with Keytruda – the blockbuster checkpoint inhibitor developed by Merck
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It follows on from similar awards in key markets such as the US, Europe, South Africa and Australia
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The FTSE 250 though, seen as a better indicator of the state of UK companies, closed down around 41 points at 19,347.
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The US patent covers Modi-1, while the European patent relates to a monoclonal antibody called FG88
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The AIM-listed group is at the vanguard of advances in the emerging field of immuno-oncology and is working on two technologies that are showing early promise
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The AIM-listed drug developer is at the vanguard of advances in the emerging field of immuno-oncology
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The company first teamed up with Sweden's world-leading medical research university two years ago
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The patent protects a new class of cancer vaccines rolling off the Moditope platform
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The AIM-listed firm said its Moditope platform acts by stimulating the production of CD4+ T cells, which seek out and kill tumour cells that would otherwise be hidden from the immune system
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