viewNoxopharm Ltd

Noxopharm accelerates towards Phase 2 trial for DARRT-2 study of anti-cancer drug Veyonda®

The Phase Two trial will broaden the scope of studies into a potential cancer treatment using a higher dose of its Veyonda® drug candidate.

Noxopharm Ltd - Noxopharm accelerates towards advanced DARRT-2 trial on cancer patients
Veyonda® is an immune-oncology drug that works with the body’s defence mechanisms to fight cancer cells

Noxopharm Ltd (ASX:NOX) is gearing up for a Phase Two trial of its anti-cancer drug Veyonda® for its upcoming DARRT-2 study. 

DARRT-2 will involve around 100 patients with progressive, metastatic prostate, breast or lung cancers that have failed standard treatment options and are eligible for low-dose, palliative external beam radiotherapy (RT) to a single lesion.

The clinical-stage drug development company will utilise a higher dose of its Veyonda® drug candidate to generate the phenomenon of the abscopal response in cancer patients. 

They will take part In the study across Australia, the US, France and Hungary at around 15 trial sites. 

Building on past results

Noxopharm chief medical officer Dr Gisela Mautner said: ”The DARRT-2 study is an important study for us as it builds on the successful results of DARRT-1.

“The difference between the two studies is that DARRT-2 will be a much bigger study and will explore a more intensive treatment with Veyonda®.

“To increase the value of the study, we have added a second trial arm to include a small number of breast and lung cancer patients.

“This will ensure that, apart from the main focus of the study in prostate cancer, we also will generate results in two additional cancer types.”

Abscopal response

The abscopal response in cancer patients is a phenomenon where an immune/inflammatory response within a single lesion following low-dose radiotherapy, in turn triggers a whole of body immune response that results in shrinkage of non-irradiated lesions elsewhere in the body.

Noxopharm chief executive officer and managing director Dr Graham Kelly said: “The abscopal response is a highly attractive cancer treatment goal because it provides the opportunity for a major anti-cancer outcome from a generally safe and minimally invasive treatment.

“The challenge is that it is a very rare phenomenon that to date has proven difficult to reproduce on a consistent basis.

“Recent research has pointed to a reason for this being the need to block a certain type of repair process called autophagy of mitochondrial DNA damaged by the radiation.

“Other research points to idronoxil, the active ingredient in Veyonda®, blocking autophagy.

“It is the combination of that effect and the drug’s known immuno-stimulatory effects, together with the earlier DARRT-1 trial data, that provides the confidence that we might have the ability to achieve consistently higher response rates to make DARRT a practical treatment option.”


Veyonda® is an immune-oncology drug that works with the body’s defence mechanisms to fight cancer cells. It moderates and inhibits cancer cell signalling and complements existing therapies like radiation treatment and chemotherapy, enhancing the efficacy of these treatments.

Quick facts: Noxopharm Ltd


Price: 0.565 AUD

Market Cap: $162.88 m

Add related topics to MyProactive

Create your account: sign up and get ahead on news and events


The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...

In exchange for publishing services rendered by the Company on behalf of named herein, including the promotion by the Company of in any Content on the Site, the Company receives from said issuer annual cash...


Noxopharm to expand NOXCOVID program following positive phase 1 results

Noxopharm Ltd (ASX:NOX)'s Graham Kelly tells Proactive they're planning to expand its NOXCOVID clinical program after receiving positive preliminary top-line data from its Phase 1 clinical trial for patients with coronavirus. The company's positioning Veyonda (idronoxil) as an anti-inflammatory...

on 24/8/21

3 min read