logo-loader
viewImugene Ltd

Imugene to make further cancer vaccine research presentations at AACR annual meeting

The AACR annual meeting will be held in Atlanta Georgia, between March 29 and April 3.

1551662441_shutterstock_306682595.jpg
Imugene is a clinical stage immune-oncology company

Imugene Ltd (ASX:IMU) will present on its KEY-Vaxx an B-Vaxx cancer vaccine programs at the American Association for Cancer Research’s (AACR) 2019 annual meeting.

The presentations will be made by Dr Tanios Bekaii-Saab from the Mayo Clinic, the co-inventor of the KEY-Vaxx and B-Vaxx cancer vaccines along with Imugene scientific advisor Professor Pravin Kaumaya.

Content from the presentations remains embargoed until the start of the conference and will be made available online after the annual meeting begins.

 

The first abstract presentation is entitled ‘Development of a novel PD-1 vaccine and in combination with two Chimeric HER-2 peptide vaccine provides synergistic inhibition of tumour growth in a syngeneic Balc/c model challenged with CT26/HER-2 carcinoma cell line’.

The second is called ‘A phase-one active immunotherapy with a combination of two Chimeric (Trastuzumab-like and Pertuzumab-like) human epiderman growth factor receptor 2 (HER-2) B cell peptide vaccine emulsified in ISA 720 and Nor-MDP adjuvant in patients with advanced solid tumours

READ: Imugene to present cancer vaccine research at AACR annual meeting

Imugene’s KEY-Vaxx is a B-cell peptide cancer vaccine designed to treat tumours such as lung cancer by interfering with PD-1/PD-L1 binding and interaction.

It is also designed to produce an anti-cancer effect similar to Keytrude, Opdivo and the other immune checkpoint inhibitor monoclonal antibodies that are transforming cancer treatment.

KEY-Vaxx when combined with B-Vaxx has shown great potential in pre-clinical studies, demonstrating robust PD-1 and HER-2 antibody responses in all vaccinated mice.

This indicates that the combined vaccination is effective in reducing tumour growth in a Balc/c syngeneic model of colon carcinoma versus either the PD-1 vaccine alone or more important the positive control gold standard that is anti-mouse PD-1 monoclonal antibody.

The vaccine combination was found to be safe and did not appear to exhibit toxicity or autoimmunity.

READ: Imugene has cancer vaccine trial data published in prestigious medical journal

B-Vaxx is a proprietary B-cell peptide cancer vaccine being developed that targets multiple oncology indications.

The phase-one B-Vaxx trial studied the side effects and best dose of vaccine therapy in treating patients with metastatic solid tumours.

The open-label, dose escalation study evaluated B-Vaxx in patients with solid tumours that over-express the HER-2/neu receptor.

B-Vaxx has been shown to stimulate a potent polyclonal antibody response to HER-2/nue, a well-established and validated cancer target.

A phase-two study evaluating the activity of B-Vaxx in patient over-expressing HER-2/nue is being conducted at clinical institutions in the US.

Quick facts: Imugene Ltd

Price: 0.036 AUD

ASX:IMU
Market: ASX
Market Cap: $130.93 m
Follow

Add related topics to MyProactive

Create your account: sign up and get ahead on news and events

NO INVESTMENT ADVICE

The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...

In exchange for publishing services rendered by the Company on behalf of Imugene Ltd named herein, including the promotion by the Company of Imugene Ltd in any Content on the Site, the Company receives from said...

FOR OUR FULL DISCLAIMER CLICK HERE

Watch

Imugene receives $4.13 million R&D tax incentive boost for commercial and...

Imugene Ltd (ASX:IMU) chief executive officer Leslie Chong and visiting US Professor Yuman Fong update Proactive on the progress of the company’s remarkable CF33 oncolytic virotherapy technology, which was acquired in July 2019. Professor Fong is the inventor of the technology and spoke about...

3 weeks, 3 days ago

3 min read