Sign up Australia
Proactive Investors - Run By Investors For Investors

Pharmaxis phase I trial attracts interest from multiple pharmaceutical companies

Final stages of phase I studies and phase II enabling toxicity studies are due to complete in Q3 2018.
lab worker
Initial results from phase I demonstrate best in class profile for LOXL2

Pharmaxis Ltd (ASX:PXS) has briefed potential partners attending the BIO18 partnering conference in Boston on data emerging from the phase I clinical studies of its anti‐fibrotic LOXL2 inhibitor program in which two compounds are showing significant inhibition of the enzyme for 24 hours with a single oral dose.  

LOXL2 or lysyl oxidase like 2 has been implicated as a key factor in various fibrotic diseases in organs such as the liver, lung, heart and kidney.

WATCH: Pharmaxis has the "secret sauce" for developing drugs through to commercialisation

Pharmaxis’ two compounds have both cleared the first stage of the studies where single oral doses of different strengths were trialled in healthy volunteers. 

There were no adverse safety findings in this first stage.   Both drugs are now entering the final stage where different fixed doses are given for 14 days.

In addition to studying their safety and pharmacokinetic profiles the two studies are also investigating the degree to which these drugs can inhibit the target enzyme LOXL2.

Importantly, Pharmaxis has been able to demonstrate a large and highly significant inhibition of this enzyme for a full 24 hours with a single oral dose.

Pharmaxis chief executive officer Gary Phillips said: “The data package being reviewed by several multinational pharmaceutical companies under confidentiality agreements is now maturing rapidly as we see the final data being generated by ongoing pre‐clinical and clinical studies. 

“There are a number of key features which have contributed to an increase in the already strong interest amongst these companies.”

The amine oxidase platform at Pharmaxis has generated small molecule enzyme inhibitors to a range of important disease targets that are at various stages of development. 

The SSAO inhibitor acquired by Boehringer is in phase II and the LOXL2 inhibitors are in phase I trials.

Meanwhile a compound inhibiting both myeloperoxidase (MPO) and SSAO and another compound inhibiting all the LOX family of enzymes are both in the final stages of pre‐clinical testing with phase I trials scheduled to commence in the next 6 to 12 months.

View full PXS profile View Profile

Pharmaxis Ltd Timeline

Related Articles

Laboratory
June 21 2018
Genedrive has signed sales agreement with Sysmex Corporation for the distribution of the HCV ID to EMEA and Asia Pacific and with Mumbai- based ARKRAY to distribute the kit in India
tumour cells
July 25 2018
Sign-off by the US Food & Drug Administration is considered the "global standard for approval", the company said
test tubes
September 11 2018
Sierra Oncology is about to start the third trial of Sareum’s SRA737 Chk1 inhibitor, while internally, Sareum is making “good progress” with its TYK2 inhibitor programme

No investment advice

The information on this Site is of a general nature only. It does not take your specific needs or circumstances into consideration, so you should look at your own financial position, objectives and requirements and seek financial advice before making any financial decisions. You acknowledge and understand that neither the Company, its related bodies corporate, the information providers or their affiliates will advise you personally about the nature, potential value or suitability of any particular security, portfolio of securities, transaction, investment strategy, or other matter. You should read our FSG and any other relevant disclosure documents and if necessary seek persona advice prior to making any investment decision.

You understand and agree that no Content (as defined below) published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is suitable or advisable for any specific person.

You understand that in certain circumstances the Company, its related bodies corporate, the information providers or their affiliates may have received, or be entitled to receive, financial or other consideration in connection with promoting, and providing information about, certain entities on the Site and in communications otherwise provided to you.

You understand that price and other data is supplied by sources believed to be reliable, that the calculations herein are made using such data, and that neither such data nor such calculations are guaranteed by these sources, the Company, the information providers or any other person or entity, and may not be complete or accurate. From time to time, reference may be made in our marketing materials to prior articles and opinions we have published. These references may be selective, may reference only a portion of an article or recommendation, and are likely not to be current. As markets change continuously, previously published information and data may not be current and should not be relied upon.

Before you act on any general advice we provide, please consider whether it is appropriate for your personal circumstances.

© Proactive Investors 2018

Proactive Investors Australia PTY LTD ACN:132787654 ABN:19132787654.

Market Indices, Commodities and Regulatory News Headlines copyright © Morningstar. Data delayed 15 minutes unless otherwise indicated. Terms of use