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ANGLE says Parsortix screening device captures prostate cancer cells

Last updated: 18:02 11 Nov 2011 AEDT, First published: 19:02 11 Nov 2011 AEDT

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ANGLE's (LON:AGL) medical diagnostics business, Parsortix, has made another important breakthrough.

Its cell separation device can capture prostate cancer cells, it was revealed today, having already been used successfully to capture cultured breast cancer cells added to human blood.

The latest results support the thesis that the device can be used to screen for any solid tumour cancers without need for modification.

If this is indeed the case, then it marks the Parsortix technology out as potentially being far more effective than the existing cancer tests, which are cancer-specific and often return false negative results.     

ANGLE founder and chief executive, Andrew Newland, said: "The successful capture and identification of prostate cancer cells added to blood further substantiates the potential for the Parsortix separation technology to become a market-leading product, which is simple, effective and affordable."

Parsortix is the jewel in the crown of the ANGLE portfolio. Its small, devilishly simple separation device has all sorts of ramifications for the way the disease is treated and monitored.

For a start it may be possible using the device to determine which treatments are working, and which are not.  

Now this promises a huge improvement in the way chemotherapy is administered. 

The device also has the potential to monitor patients in remission, and to pick up early signs of the return of the cancer, ahead of the patient experiencing any symptoms.  

The earlier the treatment, the greater the likelihood the patient will survive.

Furthermore, it may be possible to develop a simple blood test to provide routine screening of healthy people to check for early signs of cancer ahead of any symptoms.

Although still in its infancy, Parsortix technology may ultimately have the ability to identify all the hard tumour types, without knowing in advance which cancer is expected.  

This is a step on from the existing means of identifying circulating cancer cells, where the tests are specific to each cancer type and even then are not totally reliable.  

“We think ours has a much more universal application - hopefully to all solid tumours,” said Newland in a recent interview with Proactive Investors.

The company is currently in discussions with leading cancer research groups including the Paterson Institute for Cancer Research in Manchester. 

The idea of this and other similar collaborations is to field test the device using blood taken from cancer patients. 

It also allows for development of the separation device and the supporting equipment in a real world setting. 

The potential clinical market is huge and is conservatively estimated by the company to be worth around US$4 billion annually in the United States alone.

However, to be sold for use in hospitals the device requires what’s called 510k approval from the all powerful US Food & Drug Administration and a CE Mark here in Europe. 

That process is likely to take a further 18 months of research, development and testing – and cost around £5 million.

Although the company is talking to potential partners, ANGLE may bankroll the development itself. 

It has options to achieve this, including the sale of one of the businesses in the company’s portfolio.

Alternatively it could fund the work by licensing selective use of the separation device to big pharmaceutical companies developing drugs for cancer as what’s called a companion diagnostic.

“That way we would get a big partner working with us, but wouldn’t give away the crown jewels,” Newland said.

“There is the potential to take the separation device rapidly into the research sales market as this does not require regulatory approval and that is our first target.” 

ANGLE owns 90 per cent of Parsortix.

 

ANGLE PLC's Andrew Newland on 'breakthrough in culturing CTCs'

Andrew Newland, chief executive of ANGLE PLC (LON:AGL), tells Proactive's Andrew Scott that researchers using their Parsortix device for capturing circulating tumour cells may have found another “clear high value application” for the system. Not only have they discovered a method of...

on 19/4/18