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Synairgen plc: DEEP DIVE
OVERVIEW

Synairgen making headway

The company has been developing a treatment for chronic lung disease in-house and has partnered with an Australian group to develop a drug for rare liver and lung complaints
lung x-ray
OVERVIEW: SNG The Big Picture
The firm is focused on respiratory diseases
  • Focused on respiratory disease
  • Two drug candidates, one being developed in-house the other by a partner
  • Financially well set to progress its key asset, analyst says

Respiratory specialist

Synairgen plc (LON:SNG) is currently running a two-part phase II trial evaluating SNG001. This is an inhaled interferon beta drug candidate designed for people with chronic obstructive pulmonary disease (COPD) who are also suffering cold or flu infections.

It has completed the first part of its SG015 study, assessing the safety of the treatment. The second instalment is underway at 13 separate sites.

In an update, the company said the milder start to the current virus season means Synairgen expects the trial to continue into the 2019/20 peak period for cold and flu.

In the latest company release (Mar 14) Synairgen said it is to include patients with more severe chronic obstructive pulmonary disease in the second part of the mid-stage study of its SNG001 drug. The move comes after a successful interim safety review by the independent Data Safety Monitoring Committee which did not identify any safety concerns for patients currently enrolled in the trial.

LOXL2

The company’s Australian partner has completed phase I trials and toxicology on a LOXL2 inhibitor developed by Synairgen.

This now paves the way for Pharmaxis to advance discussions with potential partners for the drug, which has been developed to treat non-alcoholic liver disease (NASH) and a rare lung condition.

The company retains a 17% “carried interest” in the asset.

Synairgen’s BioBank

Over the years, Synairgen has accumulated an extensive bank comprised of blood, sputum, nasal lavage, biopsies, bronchial epithelial cells and fibroblasts from volunteers with asthma or COPD. Using this resource, the company has developed a number of advanced tissue models.

It uses these models to:

•        Discover novel drug targets

•        Identify disease-related lesions and underlying molecular mechanisms

•        Conduct proof of concept testing and validation of novel drug targets

•        Conduct screening assays for novel drug targets and lead target selection

•        Provide support for clinical trial activities

Financially solid

The company ended last year with £5.33mln in the bank, having raised £2.7mln.

What the broker says

Mark Brewer of small-cap specialist finnCap said in Feburary that year-end cash of £5.3mln was “sufficient to more than cover the cost of the ongoing phase IIa study of SNG001”. On the slower than expected sign-up rate for the trial, he added: “We are hugely reassured by the fact that all patients enrolled are virus-positive, which increases the probability of SNG001 showing a drug-related effect.”

Brewer’s price target for the stock is 54p. The shares are currently changing hands for 15p.

 

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Synairgen plc Timeline

Big Picture
May 07 2019
Article
February 25 2019

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