Advaxis rockets after promising data from key prostate cancer study unveiled

Data from the Phase 1/2 Keynote study evaluating the cancer immunotherapy ADXS-PSA was presented at the American Association for Cancer Research's annual meeting

clinical trial folder
The data for 37 patients taking part in the study showed a median overall survival rate of 21.1 months

Shares of Advaxis (NASDAQ:ADXS) soared Monday thanks to promising data from a Phase 1/2 Keynote-046 evaluating its cancer immunotherapy ADXS-PSA for the treatment of advanced prostate cancer.

The 50-patient study is evaluating ADX-PSA alone as a treatment for metastatic prostate cancer, and in combination with Keytruda, Merck's blockbuster anti-PD-1 cancer therapy.

The data for 37 patients taking part in the study showed a median overall survival rate of 21.1 months, which compares favorably to traditional therapies.

READ: Advaxis shares climb after fiscal 2Q loss comes in better than expected, cash burn subsides

Broader stimulation of the immune system, including B-cell activation, was also observed when ADX-PSA was taken with Keytruda. The combination of ADXS-PSA and Keytruda was well tolerated by participating patients as well.

In response to these results, Advaxis shares climbed 16.4% to $6.86 in afternoon trade.

“Based on the prolonged survival data and strong safety profile to date, we believe that continued clinical development of ADXS-PSA in combination with Keytruda is warranted and represents a potentially significant opportunity for Advaxis,” said Kenneth Berlin, CEO of Advaxis, in a statement.

News of the promise of clinical findings for ADXS-PSA comes on the heels of preliminary data from a Phase 1 trial of ADX-NEO, another of the company’s cancer immunotherapies, showing “substantial” anti-tumor activity.

Data from both studies were presented at the American Association for Cancer Research’s annual meeting taking place this week in Atlanta, Georgia.

Contact Ellen Kelleher at ellen@proactiveinvestors.com

Quick facts: Advaxis

Price: 0.3882 USD

Market: NASDAQ
Market Cap: $25.71 m

Add related topics to MyProactive

Create your account: sign up and get ahead on news and events


The Company is a publisher. You understand and agree that no content published on the Site constitutes a recommendation that any particular security, portfolio of securities, transaction, or investment strategy is...


Lithium Australia 'taking Elon Musk's vision to disrupt the supply chain one...

Lithium Australia NL (ASX:LIT) managing director Adrian Griffin gives his response to comments made by Elon Musk at this week's Tesla Battery Day. With Musk's ambition to minimise the steps from mining to battery production, Griffin says they've developed the technology needed to take that one...

1 day, 18 hours ago

2 min read