ValiRx PLC - Patent Status Update
("ValiRx", the "Company" or the "Group")
Patent Status Update
Notification of allowance of VAL201 for the treatment of metastatic cancer
and four other patents granted
The patents granted during 2020 and the notice received by the European Patent Office in relation to VAL201 can be found below:
Use of the peptide against cancer
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A new patent linked to the previously granted Japanese patents to strengthen the portfolio
Use of the peptide against metastases
EP number to be assigned
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Extends protection for the use of VAL201 into metastatic cancer
Use of the peptide against non-cancerous proliferative conditions
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This includes the use in the treatment of endometriosis, as well as other non-cancerous conditions hormone-driven conditions (including hyperplasia)
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The first Chinese patent granted for VAL401, granted claims include the composition of the formulation and use in the treatment of cancerous and non-cancerous disease linked to the mechanism of action
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Covers the use of VAL401 in the treatment of lung cancer
The full patent portfolio for each project can be found on the project pages of the Company's website: https://www.valirx.com/our-pipeline
"I am very pleased that we have continued to extend protection across our three core products through 2020 and into January of this year. This is an important component of value creation in the Company and a high priority for the Board."
This announcement contains inside information for the purposes of Article 7 of EU Regulation 596/2014. The Directors of the Company take responsibility for this announcement.
For further information please contact:
Tel: +44 (0) 2476 796496
Cairn Financial Advisers LLP (Nominated Adviser)
Tel: +44 (0) 20 7213 0880
Peterhouse Capital Limited (Sole Broker)
Tel: +44 (0) 20 7469 0930
Optimum Strategic Communications
Tel: +44 (0) 20 8148 3040
About ValiRx plc
ValiRx accelerates the development of treatments in oncology and women's health to improve patient lives. We provide the scientific, financial and commercial framework towards enabling rapid translation of innovative science into clinical development.
With our extensive and proven experience in research and drug development, we select and incubate promising novel drug candidates and guide them through an optimised process of development, from pre-clinical studies to clinic and investor-ready assets.
Integrating science and business
We connect diverse disciplines across scientific, technical and commercial domains, with the aim of achieving a more streamlined, less costly, drug development process. We work closely with our selected collaborators and leverage the combined expertise required for science to advance.
Lead candidates from our portfolio are out-licensed or partnered with investors through ValiRx subsidiary companies for further clinical development and commercialisation. https://www.valirx.com/
VAL201 is a short peptide being studied as a potential treatment for prostate cancer. The peptide structure is inspired by the naturally occurring androgen receptor and is designed to intercept and prevent the binding of the androgen receptor to SRC kinase - an enzyme implicated in cancerous cell growth pathways. By preventing the androgen-mediated activation of SRC kinase, VAL201 can potentially prevent cancerous cell proliferation (or growth) without interfering with other functions of either the androgen receptor or SRC kinase. This precision method, mimicking a natural process, proposes a high specificity of cancer treatment with a lower side effect profile. VAL201 was licensed from CRT (part of CRUK) and developed through preclinical development into this clinical trial in patients with advanced prostate cancer. The study was held at University College Hospital (UCLH),
About Prostate Cancer
Around 48,500 men are diagnosed with prostate cancer in the
Caution regarding forward looking statements
Certain statements in this announcement, are, or may be deemed to be, forward looking statements. Forward looking statements are identiﬁed by their use of terms and phrases such as ''believe'', ''could'', "should" ''envisage'', ''estimate'', ''intend'', ''may'', ''plan'', ''potentially'', "expect", ''will'' or the negative of those, variations or comparable expressions, including references to assumptions. These forward-looking statements are not based on historical facts but rather on the Directors' current expectations and assumptions regarding the Company's future growth, results of operations, performance, future capital and other expenditures (including the amount, nature and sources of funding thereof), competitive advantages, business prospects and opportunities. Such forward looking statements reﬂect the Directors' current beliefs and assumptions and are based on information currently available to the Directors. While management believes that these forward-looking statements are reasonable as and when made, there can be no assurance that future developments affecting the Company will be those that it anticipates.
Factors that could cause actual results to differ materially from those in the forward-looking statements include risks relating to unanticipated costs, liabilities or delays; failure or delays in research and development programs; the safety and efficacy of the Company's product candidates and the likelihood of clinical data to be positive and of such product candidates to be approved by the applicable regulatory authorities; unanticipated changes relating to competitive factors in the Company's industry; risks relating to the Company's capitalisation, resources and ownership structure, the availability of sufficient resources for company operations and to conduct or continue planned clinical development programs; the outcome of any legal proceedings; risks related to the ability to correctly estimate operating expenses; risks related to the ability to project future cash utilisation and reserves needed for contingent future liabilities and business operations; risks related to the changes in market prices of the Company's ordinary shares; the Company's ability to hire and retain key personnel; changes in law or regulations affecting the Company; international, national or local economic, social or political conditions that could adversely affect the Company and its business; conditions in the credit markets; risks associated with assumptions the Company makes in connection with its critical accounting estimates and other judgments.
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