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AIM:SLN

Silence Therapeutics PLC

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Market:
AIM
Market Cap:
£321.32 m
Price
406.00 GBX
Change
-5.58%
52 weeks high
613.80
52 weeks low
40.00

Strategy

 

Our mission is to use our technology to create a new generation of therapeutics which can improve outcomes for patients and, in the process, build shareholder value.
 

Silence’s strategy is based on translating our intellectual property, our siRNA technology and delivery systems, into successful commercial drug products. We have the expertise and the patented technology required to develop siRNA based drug candidates internally as well as to establish fruitful collaborations with suitable partners.

Ensuring appropriate target gene selection and maintaining a diversified pre-clinical engine are key aspects of our strategic approach. We aim to evaluate as many potential applications of our technology as possible in the early, more affordable phases of our candidate-generating pipeline in order to better manage risk and the costs of failure.

Our strategy plays to the strengths of our platform technology, which include:
 

Specificity

Our siRNA molecules are designed to target a single mRNA in the cell, only affecting the expression of the disease-causing gene. Our delivery systems ensure further specificity by delivering therapeutic siRNA only to one target cells in the body.
 

Modular technology

Our technology consists of two components: siRNA plus delivery system.

By engineering the siRNA molecule, a different gene can be targeted to tackle a new disease. This modular nature is the basis of our versatile platform technology.
 

Well understood mode of action

RNA interference is a well characterised natural pathway, which leads to the degradation of target mRNA. The precision of the RNA interference process translates in better predictability of the biological effects of siRNA based drugs.
 

Accelerated discovery timelines

Knowing the sequence of the human genome means that potent therapeutic siRNA molecules can be identified quickly, ready to be tested in the relevant models.

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Click here to view our Pipeline

Click here to view Our Technology

 

 

Management Team

Our management team is highly experienced in a variety of relevant sectors, from molecular biology and genetics to pharmaceutical development, BD deals and corporate finance. This combination of skill sets enables the team to effectively execute our business plan.

Chief Executive Officer
Dr. David Horn Solomon

Chief Financial Officer
Dr. Rob Quinn

Head of R&D and Chief Medical Officer
Dr. Giles Campion

VP, Head of Business Development
Dr. John Strafford

VP, Head of Human Resources
Linnea Elrington

Email - [email protected]

Corporate Headquarters - UK 
72 Hammersmith Road,
London,
W14 8TH
t +44 (0)20 3457 6900

Germany
Robert-Rössle-Str. 10
D-13125 Berlin
Germany

t +49 30 9489 2800

Key advisers

Nominated adviser and joint broker

Peel Hunt LLP
Moor House
120 London Wall
London
EC2Y 5ET
+44 (0) 20 7418 8900

Legal adviser

Covington & Burling LLP
265 Strand
London
WC2R 1BH
+44 (0) 20 7076 2000

Auditor

PricewaterhouseCoopers LLP
Abacus House
Castle Park
Cambridge
CB3 0AN
+44 (0) 1223 460055

Registrar

Link Asset Services
65 Gresham Street
London
EC2V 7NQ
+44 (0)870 402 7570

European Media & Investor Relations

Consilium Strategic Communications
41 Lothbury
London
EC2R 7HG
+44 (0) 20 3709 5700

US Investor Relations

Burns McClellan
257 Park Avenue South
15th Flr.
New York
NY
+1 (212) 213 0006

 

Number of securities in issue: 71,069,933 ordinary sharesPercentage of AIM securities not in public hands: 58.44%Last updated: 31st December 2018

 

Key advisers

Nominated adviser and joint broker

Peel Hunt LLP
Moor House
120 London Wall
London
EC2Y 5ET
+44 (0) 20 7418 8900

Legal adviser

Covington & Burling LLP
265 Strand
London
WC2R 1BH
+44 (0) 20 7076 2000

Auditor

PricewaterhouseCoopers LLP
Abacus House
Castle Park
Cambridge
CB3 0AN
+44 (0) 1223 460055

Registrar

Link Asset Services
65 Gresham Street
London
EC2V 7NQ
+44 (0)870 402 7570

European Media & Investor Relations

Consilium Strategic Communications
41 Lothbury
London
EC2R 7HG
+44 (0) 20 3709 5700

US Investor Relations

Westwicke Partners
477 Madison Avenue
Suite 621
New York
NY
+1 (443) 213-0505