18:00 Tue 20 Nov 2018
SkinBioTherapeutics - Commencement of final phase of human studies
Commencement of final phase of human studies
Commencement of final phase of human studies
The final phase of the study seeks to ensure that the original SkinBiotix® technology retains the same beneficial property to improve skin barrier health when in a cream formulation. The Company is pleased to announce that the first of its 120 volunteers commenced testing last week. Provisional results for some of the volunteers are expected to be available for analysis at the end of December with the full read out on all 120 volunteers expected during Q1 2019.
The results of this final phase will complete the data pack to share with potential global partners interested in commercialising the SkinBiotix® technology in the cosmetic skin care market.
Key milestones achieved during 2018
During the course of 2018 the Company has achieved a number of important product development milestones which have reduced investor risk and reinforced the Board's confidence in the potential of SkinBiotix® to deliver a wide range of cosmetic and dermatological applications. These applications are designed to address unmet needs in the large Cosmetic
Manufacturing scale-up and freeze drying of SkinBiotix® technology
Having previously only manufactured the SkinBiotix® technology on a laboratory scale and in a liquid format, the ability to scale up manufacture was identified as a significant development risk in the Company's admission document. In the last 12 months, the Company, working with a third party, has successfully manufactured the SkinBiotix® technology to the scale required for commercial production and to meet the needs of potential global partners.
In addition to successfully scaling up manufacture, the Company has developed a freeze dried format for its SkinBiotix® technology. The ability to freeze dry a material is a critical step in developing a successful commercial product as it extends product shelf life, enabling storage and global distribution.
Successful safety and irritancy studies of cosmetic cream formulation (phase 1 and 2)
The SkinBiotix® technology had previously only been tested in laboratory and ex vivo skin studies as a raw ingredient. In order to test safety, irritancy, and effectiveness in human studies the Company needed to develop a cosmetic formulation which can be applied to human skin.
As part of its cosmetic product development, the Company successfully developed a cream formulation which passed stability and effectiveness studies in skin models (RNS:
The Company reported that in studies of 61 healthy subjects, no significant safety or irritancy effects were observed when using up to 20 times the expected dose of SkinBiotix® for up to 15 days (RNS:
Commercial interest
SkinBioTherapeutics has engaged in discussions with a number of potential partners interested in its technology and skin health product applications.
Earlier this year, a material transfer agreement (MTA) was signed with a global consumer goods company (RNS: 3rd
Dr
"The board is pleased with the progress made so far during 2018 in achieving a number of important product development milestones which have taken the SkinBiotix® technology closer to commercialisation in a cosmetic skin product.
"SkinBiotix® can now be manufactured to a commercially relevant scale, freeze dried for extended shelf life and has been formulated into a skin cream which has shown no significant safety or irritancy effects in a human study. These milestones, both individually and collectively, have reduced development risk, changed the risk reward ratio and are intended to increase interest from potential global partners.
"The final phase of the recently commenced human studies will be used to confirm product effectiveness, allowing us to complete the data pack to share with potential global partners who may be interested in commercialising the SkinBiotix® technology in the cosmetic skin care market."
The information communicated within this announcement is deemed to constitute inside information as stipulated under the Market Abuse Regulations (EU) No. 596/2014 and has been arranged for release by
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For more information, please contact:
Dr.
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Tel: +44 (0) 161 468 2760 |
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Tel: +44 (0) 20 7213 0880 |
Turner Pope Investments (Joint Broker)
Dugald Carlean
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Tel: +44 (0) 20 3621 4120
Tel: +44 (0) 20 3861 6625 |
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Tel: +44 (0) 20 7457 2020 |
About
SkinBioTherapeutics is a life science company focused on skin health. The Company's proprietary platform technology, SkinBiotix®, is based upon discoveries made by CEO Dr.
SkinBioTherapeutics' platform applies research discoveries made on the activities of lysates derived from probiotic bacteria when applied to the skin. The Company has shown that the SkinBiotix® platform can improve the barrier effect of skin models, protect skin models from infection and repair skin models. Proof of principle studies have shown that the SkinBiotix® platform has beneficial attributes applicable to each of these areas.
SkinBioTherapeutics received seed funding from the Tech Transfer office of the
The Company joined AIM in
The Company is based in
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