Proactiveinvestors Australia Avacta Group PLC https://www.proactiveinvestors.com.au Proactiveinvestors Australia Avacta Group PLC RSS feed en Tue, 25 Jun 2019 13:42:54 +1000 http://blogs.law.harvard.edu/tech/rss Genera CMS action@proactiveinvestors.com (Proactiveinvestors) action@proactiveinvestors.com (Proactiveinvestors) <![CDATA[RNS press release - Avacta and Selexis Partner to Develop Cell Line ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190620070003_14117475/ Thu, 20 Jun 2019 16:00:03 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190620070003_14117475/ <![CDATA[RNS press release - Turner Pope Investor Evening ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190619070005_14115875/ Wed, 19 Jun 2019 16:00:05 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190619070005_14115875/ <![CDATA[RNS press release - Avacta's CSO to Present at Major US Conference ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190612070006_14107301/ Wed, 12 Jun 2019 16:00:06 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190612070006_14107301/ <![CDATA[RNS press release - Avacta hits Clinical Candidate Selection Milestone ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190610070004_14103983/ Mon, 10 Jun 2019 16:00:04 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190610070004_14103983/ <![CDATA[RNS press release - TMAC Programme Accelerates ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190603070005_14095084/ Mon, 03 Jun 2019 16:00:05 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190603070005_14095084/ <![CDATA[RNS press release - Issue of Equity ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190423154837_14048886/ Wed, 24 Apr 2019 00:48:37 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190423154837_14048886/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190412144650_14039883/ Fri, 12 Apr 2019 23:46:50 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190412144650_14039883/ <![CDATA[RNS press release - Interim Results ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190409070005_14033318/ Tue, 09 Apr 2019 16:00:05 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190409070005_14033318/ <![CDATA[RNS press release - Issue of Equity ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190308121419_13995883/ Fri, 08 Mar 2019 23:14:19 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190308121419_13995883/ <![CDATA[RNS press release - Moderna Exercises Exclusive Product License Option ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190204070004_13956274/ Mon, 04 Feb 2019 18:00:04 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190204070004_13956274/ <![CDATA[RNS press release - Director Appointment ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190128070006_13947984/ Mon, 28 Jan 2019 18:00:06 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190128070006_13947984/ <![CDATA[RNS press release - Result of Annual General Meeting ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190121154019_13941702/ Tue, 22 Jan 2019 02:40:19 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190121154019_13941702/ <![CDATA[RNS press release - AGM Business Update and Notice of Results ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190121070004_13940394/ Mon, 21 Jan 2019 18:00:04 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190121070004_13940394/ <![CDATA[RNS press release - Share Incentive Plan/Issue of Equity ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190118170824_13940202/ Sat, 19 Jan 2019 04:08:24 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190118170824_13940202/ <![CDATA[RNS press release - Change of accounting reference date ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190118100051_13939616/ Fri, 18 Jan 2019 21:00:51 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190118100051_13939616/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190109110612_13929041/ Wed, 09 Jan 2019 22:06:12 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190109110612_13929041/ <![CDATA[RNS press release - Director/PDMR Shareholdings ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190107145049_13926297/ Tue, 08 Jan 2019 01:50:49 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190107145049_13926297/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190103085621_13922589/ Thu, 03 Jan 2019 19:56:21 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190103085621_13922589/ <![CDATA[RNS press release - Director/PDMR Shareholding ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190102070006_13920078/ Wed, 02 Jan 2019 18:00:06 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20190102070006_13920078/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181221134112_13913584/ Sat, 22 Dec 2018 00:41:12 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181221134112_13913584/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181219153253_13910217/ Thu, 20 Dec 2018 02:32:53 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181219153253_13910217/ <![CDATA[RNS press release - Avacta London Science Day ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181217070006_13905328/ Mon, 17 Dec 2018 18:00:06 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181217070006_13905328/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181212125057_13901287/ Wed, 12 Dec 2018 23:50:57 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181212125057_13901287/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181212124403_13901285/ Wed, 12 Dec 2018 23:44:03 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181212124403_13901285/ <![CDATA[RNS press release - Appointment of Chief Medical Officer ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181212070002_13900080/ Wed, 12 Dec 2018 18:00:02 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181212070002_13900080/ <![CDATA[RNS press release - Posting of Annual Report and Notice of AGM ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181211070012_13898697/ Tue, 11 Dec 2018 18:00:12 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181211070012_13898697/ <![CDATA[RNS press release - Second Price Monitoring Extn ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181210140541_13897936/ Tue, 11 Dec 2018 01:05:41 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181210140541_13897936/ <![CDATA[RNS press release - Price Monitoring Extension ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181210140021_13897931/ Tue, 11 Dec 2018 01:00:21 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181210140021_13897931/ <![CDATA[RNS press release - Development Partnership with LG Chem Life Sciences ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181210070004_13896648/ Mon, 10 Dec 2018 18:00:04 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181210070004_13896648/ <![CDATA[RNS press release - Avacta to Present at Major European Conference ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181112070006_13862572/ Mon, 12 Nov 2018 18:00:06 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181112070006_13862572/ <![CDATA[RNS press release - Avacta's CTO to Present at Major US Conference ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181011070009_13824337/ Thu, 11 Oct 2018 17:00:09 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181011070009_13824337/ <![CDATA[RNS press release - Avacta agrees Affimer reagent licensing deal ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181010070004_13822536/ Wed, 10 Oct 2018 17:00:04 +1100 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181010070004_13822536/ <![CDATA[RNS press release - Preliminary Results ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181002070007_13812193/ Tue, 02 Oct 2018 16:00:07 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20181002070007_13812193/ <![CDATA[RNS press release - Investor Meeting and Presentation ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180921070004_13799295/ Fri, 21 Sep 2018 16:00:04 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180921070004_13799295/ <![CDATA[RNS press release - Notice of Results ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180905070015_13778935/ Wed, 05 Sep 2018 16:00:15 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180905070015_13778935/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180831095555_13774524/ Fri, 31 Aug 2018 18:55:55 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180831095555_13774524/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180823170746_13766660/ Fri, 24 Aug 2018 02:07:46 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180823170746_13766660/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180823170644_13766655/ Fri, 24 Aug 2018 02:06:44 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180823170644_13766655/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180823112155_13766231/ Thu, 23 Aug 2018 20:21:55 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180823112155_13766231/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180822142325_13764922/ Wed, 22 Aug 2018 23:23:25 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180822142325_13764922/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180822092038_13764323/ Wed, 22 Aug 2018 18:20:38 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180822092038_13764323/ <![CDATA[RNS press release - Result of General Meeting ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180817113022_13759735/ Fri, 17 Aug 2018 20:30:22 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180817113022_13759735/ <![CDATA[RNS press release - Holding(s) in Company ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180806162409_13745473/ Tue, 07 Aug 2018 01:24:09 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180806162409_13745473/ <![CDATA[RNS press release - Results of Placing and Subscription ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180730180633_13736685/ Tue, 31 Jul 2018 03:06:33 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180730180633_13736685/ <![CDATA[RNS press release - Proposed Placing and Subscription to raise £11.4m ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180730114143_13736078/ Mon, 30 Jul 2018 20:41:43 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180730114143_13736078/ <![CDATA[Media files - Avacta Group PLC agrees major co-development partnership with US business ]]> https://www.proactiveinvestors.com.au/companies/stocktube/9943/avacta-group-plc-agrees-major-co-development-partnership-with-us-business-9943.html Wed, 25 Jul 2018 12:20:00 +1000 https://www.proactiveinvestors.com.au/companies/stocktube/9943/avacta-group-plc-agrees-major-co-development-partnership-with-us-business-9943.html <![CDATA[RNS press release - Major Therapeutics Co-development Partnership ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180724070002_13728294/ Tue, 24 Jul 2018 16:00:02 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180724070002_13728294/ <![CDATA[News - Avacta shares jump as much as 60% after it inks co-development deal with US innovator ]]> https://www.proactiveinvestors.com.au/companies/news/201406/avacta-shares-jump-as-much-as-60-after-it-inks-co-development-deal-with-us-innovator-201406.html Shares in Avacta Group PLC (LON: AVCT) shot up as much as 60% after it said it had agreed a major co-development partnership with a US business.

It is teaming up with Bach BioSciences, a company commercialising the research of William Bachovchin, a professor at Tufts University School of Medicine, Boston.

In what is described as a “ground-breaking” co-invention, the two companies have developed a new class of drug conjugate for cancer.

Traditional antibody-drug conjugates, or ADCs, are designed to harness the targeting ability of monoclonal antibodies by linking them to cell-killing agents. 

Affimers instead of antibodies

The newly-developed technology uses Avacta’s Affimers instead of antibodies.

Its engineered proteins have several innovative and distinctive features, which could potentially make them a better tool than antibodies for therapeutic applications.

They are smaller, quicker to manufacture and easier to format than antibodies, but they maintain antibody-like biologic activity when binding a target.

Bach to the future

Bach, meanwhile, has a “novel and differentiated technology” that incorporates linker chemistry from Tufts.

This selectively releases a potent drug in the tumour without requiring a process called cellular internalisation.

The combination of the two technologies represents a step forward in the development of ADC-style cancer treatment.  

“The Affimer-drug conjugate circulates as a single molecule, in which the conjugated drug is inert,” explained Dr Amrik Basran, Avacta chief scientific officer.

“[That is] until it encounters enzymes selectively expressed in tumours, where the drug is released, and through its mechanism of action is designed to turn immunologically ‘cold’ tumours ‘hot’ and receptive to immunotherapy.

“It is our expectation that this will increase the percentage of responsive patients dramatically and, in doing so, it will make a meaningful difference to the lives of a great many cancer patients."

First Affimer drug conjugate

The first Affimer drug conjugate combines Avacta’s PD-L1 technology, which target’s cancer’s off-switch, and an I-DASH small molecule inhibitor.

Tufts is said to have “considerable” clinical data on both inhibitor types, reducing the biology risk.

“We believe that this new drug conjugate platform is transformational for the business,” said chief executive Alastair Smith. 

“From our initial discussions with several large pharmaceutical companies, it is clear that there is significant interest and there is certainly the potential for partnering at an early stage once we have the appropriate supporting data from the collaboration with Professor Bachovchin.”

Shares up strongly

The shares responded to the partnership announcement by jumping 11.75p to 40.25p, though the price was well above 50p early in the session.

finnCap, the company’s broker, reckons the stock is worth 200p.

As well as the tie-up with Bach, Avacta is partnered with Glythera Ltd, FIT Biotech and Modern Therapeutics.

Its lead programme, a PD-L1 Affimer, is on track to deliver “several pre-clinical milestones”, the company said in a recent update.

]]>
Tue, 24 Jul 2018 07:41:00 +1000 https://www.proactiveinvestors.com.au/companies/news/201406/avacta-shares-jump-as-much-as-60-after-it-inks-co-development-deal-with-us-innovator-201406.html
<![CDATA[Media files - Avacta Group Plc focused on securing third-party deals for both sides of the business ]]> https://www.proactiveinvestors.com.au/companies/stocktube/9584/avacta-group-plc-focused-on-securing-third-party-deals-for-both-sides-of-the-business-9584.html Thu, 14 Jun 2018 15:54:00 +1000 https://www.proactiveinvestors.com.au/companies/stocktube/9584/avacta-group-plc-focused-on-securing-third-party-deals-for-both-sides-of-the-business-9584.html <![CDATA[RNS press release - Appointment of Non-Executive Chairman ]]> https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180611070004_13673668/ Mon, 11 Jun 2018 16:00:04 +1000 https://www.proactiveinvestors.com.au/companies/rns/104/LSE20180611070004_13673668/