Proactiveinvestors Australia Kazia Therapeutics Ltd https://www.proactiveinvestors.com.au Proactiveinvestors Australia Kazia Therapeutics Ltd RSS feed en Wed, 24 Apr 2019 13:07:47 +1000 http://blogs.law.harvard.edu/tech/rss Genera CMS action@proactiveinvestors.com (Proactiveinvestors) action@proactiveinvestors.com (Proactiveinvestors) <![CDATA[Media files - Kazia Therapeutics to present positive ovarian cancer drug data at AACR annual meeting ]]> https://www.proactiveinvestors.com.au/companies/stocktube/12814/kazia-therapeutics-to-present-positive-ovarian-cancer-drug-data-at-aacr-annual-meeting-12814.html Mon, 01 Apr 2019 22:45:00 +1100 https://www.proactiveinvestors.com.au/companies/stocktube/12814/kazia-therapeutics-to-present-positive-ovarian-cancer-drug-data-at-aacr-annual-meeting-12814.html <![CDATA[News - Kazia Therapeutics will outline anti-cancer drug development strategy at CEO Sessions ]]> https://www.proactiveinvestors.com.au/companies/news/214129/kazia-therapeutics-will-outline-anti-cancer-drug-development-strategy-at-ceo-sessions-214129.html Kazia Therapeutics Ltd (ASX:KZA) is developing anti-cancer drugs with its pipeline including two clinical-stage drug development candidates and the company’s progress will be outlined at this month’s Proactive CEO Sessions.

Chief executive officer James Garner will present to investors at the Sydney CEO Session on Monday, February 18 and at the Melbourne session on Tuesday, February 19.

Its lead candidate is GDC-0084, which entered a phase II clinical trial in March 2018, and Kazia expects  initial data early this year followed by other data read-outs.


GDC-0084 is being developed for glioblastoma multiforme, the most common and most aggressive form of primary brain cancer.

Chemotherapy treatment temozolomide is only effective in one-third of patients.

Furthermore, the median survival rate is 12 to 15 months from diagnosis, meaning there is a demand in the market for superior treatments.

GDC-0084 value proposition

The GDC-0084 value proposition is considerable:

• Currently in Phase II clinical trials, under IND with US FDA, at leading US centese for brain cancer;
• Clear Phase I data, with favourable safety profile and indications of efficacy in late-stage GBM patients;
• Clear unmet medial need, with only existing therapy working in about 35% of patients;
• Defined >US$1 billion market potential for GBM alone;
• PI3K is a well-validated onco-target, with three existing therapies on market, but GDC0084 uniquely differentiated by ability to cross blood-brain barrier;
• Key inflection point due in 2H 2019, and additional indication investigator studies ongoing with updates in 2019; and
• High potential for accelerated approval by FDA.

Cantrixil in clinical trial

As well as GDC-0084, Kazia is developing Cantrixil to treat ovarian cancer which is currently in a phase I clinical trial in Australia and the United States.

Cantrixil is a third-generation benzopyran molecule with activity against cancer stem cells.

Kazia expects a read-out of maximum tolerated dose and safety from its phase I study in ovarian cancer in the current June half.

The Sydney-based oncology-focused biotechnology company is well-funded to see both programs through key data read-outs.

Register for the CEO Sessions today to find out more.

Sydney details, Monday, February 18, 2019

Melbourne details, Tuesday, February 19, 2019

Also featuring at both sessions will be AdAlta Ltd (ASX:1AD), Argonaut Resources NL (ASX:ARE) and Peninsula Energy Ltd (ASX:PEN) while Theta Gold Mines Ltd (ASX:TGM) is on the Sydney program and Anatara Lifesciences Ltd (ASX:ANR) is on the Melbourne program.

 

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Thu, 07 Feb 2019 11:35:00 +1100 https://www.proactiveinvestors.com.au/companies/news/214129/kazia-therapeutics-will-outline-anti-cancer-drug-development-strategy-at-ceo-sessions-214129.html
<![CDATA[News - Kazia Therapeutics progresses phase II clinical trial for brain cancer drug ]]> https://www.proactiveinvestors.com.au/companies/news/193977/kazia-therapeutics-progresses-phase-ii-clinical-trial-for-brain-cancer-drug-193977.html Kazia Therapeutics Ltd (ASX:KZA) (NASDAQ:KZIA) has commenced an international phase II clinical trial of its lead program, GDC-0084, a developing brain cancer drug.

GDC-0084 is being developed for glioblastoma multiforme, the most common and most aggressive form of primary brain cancer.

Chemotherapy treatment temozolomide is only effective in one-third of patients.

Furthermore, the median survival rate is 12 to 15 months from diagnosis, meaning there is a demand in the market for superior treatments.

Kazia’s CEO Dr James Garner said: “The need for new therapies in this disease remains immense, and we believe that GDC-0084 may have a valuable role to play in improving outcomes for patients with glioblastoma.”

FDA grant in February paved way for phase II clinical trial

Commencement of the trial follows the decision of the US FDA to grant orphan drug designation to GDC-0084 in glioblastoma in February 2018.

This phase II study will initially be conducted predominantly at leading US-based centres.

The study will commence screening patients after the Easter holidays.

It is anticipated that the study will provide an initial data read-out in early calendar 2019.

Phase II builds on a successful phase I study

Kazia licensed GDC-0084 in late 2016 from Genentech, a member of the Roche Group, where it had previously completed a phase I clinical study in 47 patients with advanced glioma.

Genentech’s phase I study demonstrated a favourable safety profile and provided signals of efficacy.

Genentech also conducted an extensive preclinical program which showed encouraging results for GDC-0084 in animal models of glioblastoma.

Two clinical-stage programs

Kazia is an emerging cancer-focused biotech with two clinical-stage programs.

As well as GDC-0084, Kazia is developing Cantrixil to treat ovarian cancer which is currently in phase I trial.

Kazia expects a read-out of maximum tolerated dose and safety from its phase I study in ovarian cancer in the current June half.

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Thu, 29 Mar 2018 08:28:00 +1100 https://www.proactiveinvestors.com.au/companies/news/193977/kazia-therapeutics-progresses-phase-ii-clinical-trial-for-brain-cancer-drug-193977.html