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Additional information
Additional Information
Market: ASX
Sector: Pharma & Biotech
Epic: POH
News: Latest news
Web Site: Phosphagenics Limited
Other Articles: 02-12-200904-11-200915-09-2009

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Phosphagenics Limited

Phosphagenics Limited

Phosphagenics is a Melbourne-based, globally driven biotechnology company focused on the discovery of new and cost effective ways to enhance the bioavailability, activity, safety and delivery of proven pharmaceutical and personal care products
Wednesday, December 02, 2009

Phosphagenics initiates Phase 1B clinical trial for patented oxycodon patch

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Dual-listed Phosphagenics (ASX: POH; OTCQX: PPGNY) has initiated a Phase 1B clinical trial for its patented oxycodone/TPM (Targeted Penetration Matrix) transdermal patch systems.

The clinical trial consists of a pharmacokinetic study in twenty healthy volunteers at the Royal Adelaide Hospital.

The primary objective of the Company’s Phase 1B clinical trial is to compare two transdermal patch candidates, a matrix and reservoir system, to deliver oxycodone.

The results of the Phase 1B trial, scheduled to be completed by early 2010.

It will determine which of the two patch systems is best suited for commercial development.

The best candidate will be advanced into Phase II/III oxycodone clinical trials scheduled for 2010.

Phosphagenics’ chief operating officer, Dr Esra Ogru, said the TPM/oxycodone patch system appears potentially suitable for chronic pain management.

“The results of our first trial earlier this year were a world first and were suggestive of the potential for the TPM system to change the way in which chronic pain could be treated in the future,” she said.

“Currently, patients treated with oral oxycodone obtain pain relief for only a short period of time. The earlier human trial conducted by Phosphagenics, indicates that our oxycodone patch may provide sustained drug delivery for a matter of days.

Phosphagenics aims to become the first company to offer chronic pain sufferers an oxycodone patch that will provide sustained pain relief. In a clinical trial conducted earlier this year on 50 subjects, Phosphagenics was able to demonstrate that its formulation did not cause sensitisation or irritation, one of the major barriers preventing the use of most opioids in topical delivery systems.

US sales of oxycodone, one of the leading drugs for pain management, exceed US$1.5 billion annually.

Recently, the company raised $7 million via an underwritten share purchase plan at 9.2 cents a share.

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